Respiratory failure & ventilation
Intraocular pressure changes during ventilator weaning: a prospective observational study highlighting PaCO₂-related physiological monitoring signals in ICU patients
Authors' conclusion
The transition from mechanical ventilation to spontaneous breathing in ICU patients was not associated with a significant increase in mean IOP. However, small individual-level IOP increases were observed, and these were associated with increases in PaCO₂ during weaning.
Study context
- Population
- Adult ICU patients receiving mechanical ventilation and undergoing weaning (excluding glaucoma, prior ocular surgery, inability to tolerate weaning)45 analysed
- Participants
- 64 patients
- Outcome
- IOP change during ventilator weaning (before weaning T0, during spontaneous breathing T1, after weaning T2)
Methodological detailsT1 obtained 30 min after initiation of spontaneous breathing and T2 30 min after completion of weaning, under standardized bedside ICU conditions
- T1 obtained 30 min after initiation of spontaneous breathing and T2 30 min after completion of weaning, under standardized bedside ICU conditions
Main finding
As reported in the abstract
Mean IOP over time
- Mean intraocular pressure (IOP) values showed minimal change over time
Observational data: associations, not effects.
Further findings
Protocol-defined IOP increase (≥ 1.0 mmHg in at least one eye, T0 to T2) associated with ΔPaCO₂
| OR (95% CI) | P value | ||
|---|---|---|---|
| ΔPaCO₂Exploratory multivariable logistic regression | 1.66 (1.13–2.45) | P = 0.010 | |
| 0.512Odds ratio (log scale) |
- No significant associations with other ventilator-related or clinical variables
Original publication
Intraocular pressure changes during ventilator weaning: a prospective observational study highlighting PaCO₂-related physiological monitoring signals in ICU patients. J Clin Monit Comput. Published 20 May 2026. doi:10.
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