Intraoperative fentanyl versus paracetamol for ultrasound-guided oocyte retrieval analgesia: a randomised clinical trial
Authors' conclusion
Intra-operative IV paracetamol 1000 mg was non-inferior to fentanyl 100 μg for post-procedure analgesia
Study context
- Population
- Healthy women with ≤15 follicles undergoing ultrasound-guided oocyte retrieval under GA (propofol)95 analysed
- Participants
- 100 women
- Comparison
- Intravenous (IV) paracetamol 1000 mg vs IV fentanyl 100 μg within multimodal GA
- Primary endpoint
- Median postoperative pain numerical rating scale (NRS) score (0–10) at five predefined time points
- Follow-up
- Within the first two postoperative hours
Methodological detailssingle-centre, single-blinded, non-inferiority
- Single-centre
- Single-blinded
- Non-inferiority
Primary result
As reported in the abstract
Postoperative pain NRS
Paracetamol
0
Median · IQR 0–1
Fentanyl
0
Median · IQR 0–1
P = 0.31
Secondary outcomes
Low Pasero sedation score
P = 0.98
Median
| Outcome | Paracetamol | Fentanyl | P value |
|---|---|---|---|
| Patient satisfaction (5-point Likert) | 5 | 5 | P = 0.90 |
Aldrete scores, postoperative analgesia use, prolonged discharge time (>60 minutes)
- No differences between groups
Original publication
Intraoperative fentanyl versus paracetamol for ultrasound-guided oocyte retrieval analgesia: a randomised clinical trial. Int J Obstet Anesth. Published 10 May 2025. doi:10.
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