Perioperative medicine & outcomes
Intraoperative Goal-Directed Fluid Therapy and Outcomes After Oncologic Surgeries: A Systematic Review and Meta-Analysis
Authors' conclusion
Our systematic review and meta-analysis suggests that in oncologic surgery, intraoperative GDFT significantly reduces the length of hospital stay, lowers the risk of complications, and facilitates bowel function recovery.
Study context
- Population
- Patients undergoing oncologic surgery24 randomized controlled trials (RCTs)
- Participants
- 1,172 vs 1,186
- Comparison
- Intraoperative goal-directed fluid therapy (GDFT) vs routine clinical care
- GDFTn = 1,172
- Routine caren = 1,186reference
- Outcome
- Hospital LOS and total incidence of postoperative complications
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
GDFT vs Routine careRelative risk (95% CI)P value
Incidence of complications
0.74(0.56–0.97)
P = 0.03- Hospital LOS; significantly shorter with GDFT
- MD 1.57 days (95% CI −2.29 to −0.85); P < 0.01
Further pooled results
| Outcome | MD (days) (95% CI) | P value |
|---|---|---|
| Time to bowel function recoveryShorter with GDFT | 0.58 (−1.02 to −0.14) | P = 0.01 |
Longer-term oncologic outcomes
- Not reported by any included trial
Original publication
Intraoperative Goal-Directed Fluid Therapy and Outcomes After Oncologic Surgeries: A Systematic Review and Meta-Analysis. Anesth Analg. Published 13 November 2024. doi:10.
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