Perioperative medicine & outcomes
Intraoperative hypotension and adverse postoperative outcomes: a systematic review and meta-analysis of randomised controlled trials
Pooled resultResult — go to the resultRelative risk 1.06 95% CI 0.77–1.45Authors' conclusion
Higher vs lower intraoperative MAP did not affect all-cause 30-day mortality, AKI, or myocardial injury; however, only limited differences in blood pressure were achieved between study groups.
Study context
- Population
- Adults undergoing noncardiac surgery
- Participants
- 14,658 adults · 9 RCTs
- Comparison
- Higher vs lower intraoperative MAP target
- Outcome
- All-cause mortality
- Follow-up
- Within 30 days of surgery
Pooled result
As reported in the abstract
Relative risk
1.06
95% CI 0.77–1.45
Intervention vs Control
RR 1.06 (95% CI 0.77–1.45)
Further pooled results
Acute kidney injury (AKI), myocardial injury
- No differences for secondary outcomes in 13 RCTs
Difference in achieved intraoperative MAP (exploratory)
- Differences in intraoperative MAP between groups not associated with study outcomes
Original publication
Intraoperative hypotension and adverse postoperative outcomes: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. Published 10 August 2026. doi:10.
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