Respiratory failure & ventilation
Intraoperative individualization of positive-end-expiratory pressure through electrical impedance tomography or esophageal pressure assessment: a systematic review and meta-analysis of randomized controlled trials
Pooled result · Intraoperative PaO2/FiO2Result — go to the resultMean difference 69.6 mmHg 95% CI 32.–106.4Authors' conclusion
In patients undergoing abdominal or pelvic surgery with an open or laparoscopic/robotic approach, PEEP personalized by EIT or Pes allowed the achievement of a better intraoperative oxygenation compared to PEEP not individualized through EIT or Pes.
Study context
- Population
- Patients undergoing abdominal or pelvic surgery (open or laparoscopic/robotic) under GA
- Participants
- 240 patients · 6 RCTs
- Comparison
- Positive end-expiratory pressure (PEEP) individualized by electrical impedance tomography (EIT) or pressure (Pes) vs PEEP not tailored on EIT or Pes
- Interventionn = 117
- Controln = 123reference
- Outcome
- Intraoperative PaO2/FiO2
Methodological detailsmeta-regression
- Meta-regression
Pooled result
As reported in the abstract
Mean difference
69.6 mmHg
95% CI 32.–106.4
Intervention vs Control
mean difference 69.6 mmHg (95% CI 32.–106.4)
Further pooled results
| Outcome | Estimate (95% CI) | P value |
|---|---|---|
| Meta-regression moderated for BMI | 3.45 (0.78–6.11) | P = 0.011 |
- Meta-regression moderated for BMI: between-study heterogeneity diminished to 44.96%
Original publication
Intraoperative individualization of positive-end-expiratory pressure through electrical impedance tomography or esophageal pressure assessment: a systematic review and meta-analysis of randomized controlled trials. J Clin Monit Comput. Published 21 October 2023. doi:10.
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