Respiratory failure & ventilation
Individualised positive end-expiratory pressure titrated intra-operatively by electrical impedance tomography optimises pulmonary mechanics and reduces postoperative atelectasis: A randomised controlled trial
Authors' conclusion
Individualised PEEP by EIT may improve intra-operative pulmonary mechanics and oxygenation without impairing haemodynamic stability, and decrease postoperative atelectasis.
Study context
- Population
- Patients undergoing robotic-assisted laparoscopic hepatobiliary and pancreatic surgery under GA
- Participants
- 75 patients
- Comparison
- Individualised electrical impedance tomography (EIT)-titrated positive end-expiratory pressure (PEEP) vs PEEP 5 cmH2O during pneumoperitoneum
- PEEPEITn = 50
- PEEP5 cmH2On = 25reference
- Primary endpoint
- Respiratory system compliance during laparoscopic surgery
Methodological details2 : 1 randomisation, single-centre
- 2 : 1 randomisation
- Single-centre
Primary result
As reported in the abstract
Respiratory system compliance (mean values during surgery)
P < 0.001
Secondary outcomes
Driving pressure
P < 0.001
Postoperative atelectasis (lung tissue mass)
P = 0.003
| Outcome | PEEPEIT | PEEP5 cmH2O | P value |
|---|---|---|---|
| Oxygenation (PaO2/FiO2) | mean 427.5 ± 28.6 | mean 366.8 ± 36.4 | P = 0.003 |
Haemodynamic values
- Did not differ significantly between the groups
Safety
- No adverse effects observed during surgery
Original publication
Individualised positive end-expiratory pressure titrated intra-operatively by electrical impedance tomography optimises pulmonary mechanics and reduces postoperative atelectasis: A randomised controlled trial. Eur J Anaesthesiol. Published 13 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →