Intraoperative landmark-based genicular nerve block versus periarticular infiltration for postoperative analgesia in total knee arthroplasty: a randomized non-inferiority trial
Authors' conclusion
GNB compared with PAI provides non-inferior resting pain relief. Non-inferiority was not established for pain during movement.
Study context
- Population
- Patients undergoing total knee arthroplasty139 completed
- Participants
- 140 patients
- Comparison
- GNB vs periarticular infiltration (PAI)
- Primary endpoint
- Pain scores at rest and during movement (11-point NRS); non-inferiority margin 1
- Follow-up
- 12 hours postoperatively
Methodological detailsnon-inferiority
- Non-inferiority
Primary result
As reported in the abstract
Pain scores (11-point NRS) at rest and during movement
| Group | Value | Condition |
|---|---|---|
| PAI | median 0 (range 0–2) | at rest |
| GNB | median 0 (range 0–2) | at rest |
| PAI | median 1.5 (range 0–2.3) | during movement |
| GNB | median 2 (range 1–3.1) | during movement |
Value
PAImedian 0 (range 0–2)
GNBmedian 0 (range 0–2)
PAImedian 1.5 (range 0–2.3)
GNBmedian 2 (range 1–3.1)
Condition
PAIat rest
GNBat rest
PAIduring movement
GNBduring movement
Further findings
IV morphine consumption and time to first rescue analgesia · 12 hours postoperatively
- GNB group had higher IV morphine consumption at 12 hours and a shorter time to first rescue analgesia
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Intraoperative landmark-based genicular nerve block versus periarticular infiltration for postoperative analgesia in total knee arthroplasty: a randomized non-inferiority trial. Reg Anesth Pain Med. Published 28 October 2023. doi:10.
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