Perioperative medicine & outcomes

Intraoperative tight blood glucose control reduces the incidence of postoperative pneumonia in minimally invasive esophagectomy: A randomized clinical trial

Anaesth Crit Care Pain MedPublished Randomised controlled trial

Primary result · Postoperative pneumoniaResult — go to the resultOdds ratio 0.569 95% CI 0.39–0.83

Authors' conclusion

Intraoperative tight blood glucose control is beneficial in reducing the incidence of postoperative pneumonia for minimally invasive esophagectomy patients.

Study context

Population
Patients undergoing minimally invasive esophagectomy84 analysed
Participants
88 patients
Comparison
Tight vs non-tight intraoperative blood glucose control
  • Tight blood glucose controln = 44
  • Non-tight blood glucose controln = 44reference
Primary endpoint
Incidence of postoperative pneumonia
Methodological detailssingle-blind
  • Single-blind

Primary result

Postoperative pneumonia

Odds ratio

0.569

95% CI 0.39–0.83

P = 0.011

Events by treatment group

Tight blood glucose control vs Non-tight blood glucose control
OR 0.569 (95% CI 0.39–0.83); P = 0.011

As reported in the abstract

Secondary outcomes

Demand for advanced antibiotics

P = 0.034

OutcomeTight blood glucose controlNon-tight blood glucose controlP value
C-reactive protein · POD 178.3 (range 30.4–103.7)95.6 (range 79.0–130.5)P = 0.008

Original publication

Intraoperative tight blood glucose control reduces the incidence of postoperative pneumonia in minimally invasive esophagectomy: A randomized clinical trial. Anaesth Crit Care Pain Med. Published 15 October 2025. doi:10.1016/j.accpm.2025.101645

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