Effect of Volatile Anesthesia Versus Intravenous Anesthesia on Postoperative Pulmonary Complications in Patients Undergoing Minimally Invasive Esophagectomy: A Randomized Clinical Trial
Primary result · Pulmonary complications, volatile (sevoflurane or desflurane) vs propofolResult — go to the resultOdds ratio 0.63 95% CI 0.44–0.91Authors' conclusion
In patients undergoing minimally invasive esophagectomy, the use of volatile anesthesia (sevoflurane or desflurane) resulted in the reduced risk and severity of pulmonary complications within the first 7 postoperative days as compared to propofol-based intravenous anesthesia.
Study context
- Population
- Patients scheduled for minimally invasive esophagectomy for esophageal cancer553 analysed
- Participants
- 558 patients
- Comparison
- Volatile anesthesia vs propofol-based intravenous anesthesia
- Sevofluranen = 185
- Desfluranen = 185
- Propofoln = 183reference
- Primary endpoint
- Incidence of pulmonary complications (collapsed composite:
- Respiratory infection
- Pleural effusion
- Pneumothorax
- Atelectasis
- Respiratory failure
- Bronchospasm
- PE
- Aspiration pneumonitis)
- Follow-up
- Within 7 days postoperatively
Methodological detailsthree-arm
- Three-arm
Primary result
As reported in the abstract
Pulmonary complications, volatile (sevoflurane or desflurane) vs propofol
Odds ratio
0.63
95% CI 0.44–0.91
P = 0.013
By group
Volatile (sevoflurane or desflurane) vs Propofol
OR 0.63 (95% CI 0.44–0.91); P = 0.013
Secondary outcomes
| Outcome | P value |
|---|---|
| Severity grade of pulmonary complicationsVolatile (sevoflurane or desflurane) vs Propofol · lower severity with volatile | P = 0.035 |
Other secondary outcomes
- No statistically significant differences between the 2 groups
Original publication
Effect of Volatile Anesthesia Versus Intravenous Anesthesia on Postoperative Pulmonary Complications in Patients Undergoing Minimally Invasive Esophagectomy: A Randomized Clinical Trial. Anesth Analg. Published 9 February 2024. doi:10.
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