Cardiothoracic & vascular anesthesia
Effect of volatile versus propofol anaesthesia on major complications and mortality after cardiac surgery: a multicentre randomised trial
Authors' conclusion
Among adults undergoing cardiac surgery, we found no difference in the clinical effectiveness of volatile anaesthesia and propofol-based TIVA.
Study context
- Population
- Adults undergoing elective cardiac surgery in 16 tertiary hospitals in China3,083 in modified ITT analysis
- Participants
- 3,123 adults
- Comparison
- Volatile anaesthesia vs propofol-based total intravenous anaesthesia (TIVA)
- Volatilen = 1,531
- TIVAn = 1,552reference
- Primary endpoint
- Composite of:
- Predefined major complications during hospitalisation
- Mortality 30 days after surgery
- Follow-up
- 30 days
Methodological detailsmulticentre, 1:1 randomisation
- Multicentre
- 1:1 randomisation
Primary result
As reported in the abstract
Each group vs TIVAEstimate (CI)P value
Volatile
RR 1.02(0.92–1.12)
P = 0.76Volatile
aOR 1.05(0.90–1.22)
P = 0.57Secondary outcomes
6-month and 1-yr mortality, duration of mechanical ventilation, ICU and hospital LOS, healthcare costs
- Similar for the two groups
Original publication
Effect of volatile versus propofol anaesthesia on major complications and mortality after cardiac surgery: a multicentre randomised trial. Br J Anaesth. Published 5 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →