Cardiothoracic & vascular anesthesia
Total Intravenous Anesthesia (TIVA) vs Volatile Anesthesia in Coronary Artery Bypass Grafting (CABG) Surgery: Effects on Inflammatory and Cognitive Outcomes
Authors' conclusion
TIVA and volatile anesthesia resulted in similar perioperative IL-6 responses in patients undergoing CABG. However, TIVA was associated with better early postoperative cognitive function and faster emergence from mechanical ventilation.
Study context
- Population
- Adults aged 18 to 65 years scheduled for elective on-pump CABG, tertiary academic centre
- Participants
- 50 adults
- Comparison
- Propofol-based TIVA vs sevoflurane-based volatile anaesthesia
- Primary endpoint
- Serum interleukin-6 (IL-6) levels
- Follow-up
- Preoperatively and at 24 and 48 hours postoperatively
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
As reported in the abstract
Serum IL-6 · 24 and 48 hours
- IL-6 increased significantly at 24 h and decreased by 48 h in both groups; no significant intergroup difference at any time point
Secondary outcomes
Mini-Mental State Examination scores · 24 and 48 hours
- Significantly higher in the TIVA group
Mechanical ventilation duration
- Shorter with TIVA
VIS, cardiac function, renal parameters, ICU LOS
- Comparable between groups
Original publication
TIVA vs Volatile Anesthesia in CABG Surgery: Effects on Inflammatory and Cognitive Outcomes. J Cardiothorac Vasc Anesth. Published 21 August 2025. doi:10.
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