Perioperative medicine & outcomes
Intraoperative Use of Albumin in Major Noncardiac Surgery: Incidence, Variability, and Association With Outcomes
Authors' conclusion
Intravenous albumin is commonly administered among noncardiac surgeries with significant inter-institutional variability in use in the United States. Albumin administration was associated with an increased risk of postoperative complications.
Study context
- Population
- Adults undergoing major noncardiac surgery under GA at 54 US hospitals (Multicenter Perioperative Outcomes Group), January 2014–June 2020
- Participants
- 614,215 major surgeries
- Exposure
- Intraoperative albumin exposed vs unexposed
- Outcome
- Incidence of albumin administration
Methodological detailsobservational, multicentre, propensity score-matched
- Observational
- Multicentre
- Propensity score-matched
Main finding
As reported in the abstract
Predominantly iso-oncotic albumin administered (proportion of cases)
15.3%
Observational data: associations, not effects.
Secondary outcomes
Acute kidney injury (AKI)
- Albumin use associated with AKI, aOR
- 1.24 (95% CI 1.20-1.28, P <0.001)
- Propensity score-matched cohort (n=153,218)
Severe AKI
- Albumin use associated with severe AKI, aOR
- 1.45 (95% CI 1.34-1.56, P <0.001)
- Propensity score-matched cohort (n=153,218)
Net-positive fluid balance
- Albumin use associated with net-positive fluid balance, aOR
- 1.18 (95% CI 1.16-1.20, P <0.001)
- Propensity score-matched cohort (n=153,218)
Pulmonary complications
- Albumin use associated with pulmonary complications, aOR
- 1.56 (95% CI 1.30-1.86, P <0.001)
- Propensity score-matched cohort (n=153,218)
30-day all-cause mortality
- Albumin use associated with 30-day all-cause mortality, aOR
- 1.37 (95% CI 1.26-1.49, P <0.001)
- Propensity score-matched cohort (n=153,218)
Original publication
Intraoperative Use of Albumin in Major Noncardiac Surgery: Incidence, Variability, and Association With Outcomes. Ann Surg. Published 14 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →