Intravenous dexmedetomidine and blood loss during cesarean delivery under neuraxial anesthesia: a single-center retrospective study (2012–2016)
Main finding · Quantitative intraoperative blood lossResult — go to the resultWeighted mean difference + 57 mL 95% CI - 39 to 153Authors' conclusion
In this propensity-weighted cohort, intraoperative dexmedetomidine after cord clamping did not reduce blood loss during cesarean delivery.
Study context
- Population
- Cesarean delivery under neuraxial anesthesia, tertiary hospital in Japan, January 2012–December 2016
- Participants
- 790 cases
- Exposure
- IV dexmedetomidine after cord clamping vs no dexmedetomidine
- Dexmedetomidinen = 374
- No dexmedetomidinen = 416reference
- Outcome
- Quantitative intraoperative blood loss
Methodological detailssingle-centre, stabilized inverse-probability weighting (propensity score)
- Single-centre
- Stabilized inverse-probability weighting (propensity score)
Main finding
As reported in the abstract
Weighted mean difference
+ 57 mL
95% CI - 39 to 153
Observational data: associations, not effects.
Secondary outcomes
Calculated blood loss (Gross and hemoglobin-balance methods)
- Results directionally consistent
Intraoperative transfusion of blood products
- Did not differ
Original publication
Intravenous dexmedetomidine and blood loss during cesarean delivery under neuraxial anesthesia: a single-center retrospective study (2012–2016). Int J Obstet Anesth. Published 30 January 2026. doi:10.
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