Intravenous lidocaine with propofol‐based sedation for colonoscopy: a systematic review and meta‐analysis with trial sequential analysis
Pooled result · Propofol consumption during the procedureResult — go to the resultMean difference −42.93 mg 95% CI −62.89 to −22.97Authors' conclusion
In patients undergoing colonoscopy, the addition of intravenous lidocaine to propofol-based sedation reduced propofol consumption, shortened awakening time, mitigated post-procedural pain and enhanced patient satisfaction compared with placebo.
Study context
- Population
- Patients undergoing colonoscopy with propofol-based sedation
- Participants
- 520 patients · 8 RCTs
- Comparison
- IV lidocaine vs placebo as adjuvant to propofol-based sedation
- Outcome
- Total propofol dose
Methodological detailstrial sequential analysis, random-effects model
- Trial sequential analysis
- Random-effects model
Pooled result
Propofol consumption during the procedure
Mean difference
−42.93 mg
95% CI −62.89 to −22.97
Lidocaine vs Placebo
mean difference −42.93 mg (95% CI −62.89 to −22.97)
As reported in the abstract
Further pooled results
| Outcome | Mean difference (minutes) (95% CI) | |
|---|---|---|
| Awakening time | −3.38 (−5.92 to −0.84) | |
| −10−505Difference, minutes (linear scale) |
| Outcome | Mean difference (95% CI) | |
|---|---|---|
| Post-procedural pain scores | −1.38 (−2.72 to −0.04) | |
| Patient satisfaction scores | 0.50 (0.30–0.70) | |
| −4−202Difference (linear scale) |
Procedure duration and endoscopist satisfaction scores
- No significant differences between the groups
Safety
- No significant differences between the groups in risk of hypoxia or hypotension
Original publication
Intravenous lidocaine with propofol‐based sedation for colonoscopy: a systematic review and meta‐analysis with trial sequential analysis. Anaesthesia. Published 18 March 2025. doi:10.
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