Intravenous Methadone versus Intrathecal Morphine as Part of an Enhanced Recovery After Cardiac Surgery Protocol on Postoperative Pain and Outcomes: A Retrospective Cohort Study
Main finding · Pain scoresResult — go to the resultAverage marginal effect 0.49 95% CI 0.002–0.977Authors' conclusion
ITM when compared with IV methadone was associated with a decrease in pain scores without any difference in opioid consumption after elective cardiac surgery.
Study context
- Population
- Adults undergoing elective cardiac surgery with an enhanced recovery pathway, January 2020 to July 2021
- Participants
- 289 adults
- Exposure
- Intrathecal morphine (ITM) vs intravenous (IV) methadone within an Enhanced Recovery After Cardiac Surgery (ERACS) pathway
- Outcome
- Postoperative pain scores and opioid consumption (oral morphine equivalents)
Methodological detailstwo-centre
- Two-centre
Main finding
Pain scores · POD 0
Average marginal effect
0.49
95% CI 0.002–0.977
P = 0.049
As reported in the abstract
Observational data: associations, not effects.
Original publication
Intravenous Methadone versus Intrathecal Morphine as Part of an Enhanced Recovery After Cardiac Surgery Protocol on Postoperative Pain and Outcomes: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. Published 3 July 2024. doi:10.
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