Hemodynamics, fluids & transfusion
Intravenous vitamin C for vasoplegia: A double-blinded randomised clinical trial (VALENCIA trial)
Authors' conclusion
In this RCT of patients with vasoplegic shock of at least moderate severity, the use of IV vitamin C compared with placebo did not significantly reduce the duration of vasopressors.
Study context
- Population
- ICU patients with vasoplegic shock requiring >10 μg/min noradrenaline after hypovolaemia clinically excluded, Perth, Australiarandomised
- Participants
- 71 patients
- Comparison
- IV vitamin C vs placebo
- Vitamin Cn = 35
- Placebon = 36reference
- Primary endpoint
- Duration of vasopressor usage (hours)
Methodological detailsdouble-blinded, two ICUs
- Double-blinded
- Two ICUs
Primary result
As reported in the abstract
Vasopressor duration
P = 0.057
Secondary outcomes
ICU and hospital LOS; 28-day, ICU and hospital mortality
- Similar between groups
Original publication
Intravenous vitamin C for vasoplegia: A double-blinded randomised clinical trial (VALENCIA trial). J Crit Care. Published 19 July 2023. doi:10.
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