Perioperative medicine & outcomes
Introducing a free-breathing MRI method to assess peri-operative myocardial oxygenation and function: A volunteer cohort study
Authors' conclusion
Breathing manoeuvres simulating induction of general anaesthesia cause dynamic alterations of myocardial oxygenation in young volunteers, which can be quantified continuously with free-breathing OS-CMR.
Study context
- Population
- Healthy volunteers younger than 45 years performing breathing simulating induction of GA29 analysed
- Participants
- Thirty-two participants
- Exposure
- Traditional breath-hold oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR) vs two free-breathing OS-CMR sequences during a simulated induction breathing manoeuvre
- Outcome
- Myocardial oxygenation response at end of paced breathing and at 30 s of subsequent apnoea
Methodological detailssingle-centre, Recruitment August 2020 to January 2022
- Single-centre
- Recruitment August 2020 to January 2022
Main finding
As reported in the abstract
Myocardial oxygenation change after paced breathing and 5 deep breaths
OS bh-cine
−6.0
SD 2.6 · %
OS fb-ss
−12.0
SD 5.9 · %
OS fb-rtcine
−5.4
SD 7.0 · %
- Significant reduction with all three techniques
- all P < 0.05
Observational data: associations, not effects.
Further findings
Myocardial oxygenation change during subsequent apnoea
- Myocardial oxygenation change during subsequent apnoea — Significant increase with all three techniques
- all P < 0.01
Free-breathing vs original sequence
- Free-breathing sequences reproducible and not inferior to original sequence at any stage
Original publication
Introducing a free-breathing MRI method to assess peri-operative myocardial oxygenation and function: A volunteer cohort study. Eur J Anaesthesiol. Published 6 February 2024. doi:10.
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