Investigating Fibrinolysis Resistance in Sepsis Using High‐Multiplex Plasma Proteomics: A Statistical Analysis Plan
Study context
- Population
- Critically ill patients with sepsiscritically ill patients with sepsis, 89 samples collected serially
- Participants
- 32 patients
- Planned comparison
- Protein associations with TPA-LT/FIBA10 across the fibrinolysis resistance severity continuum, between three ordinal severity grades, and over time within individual patients
Methodological detailspre-specified, serial sampling, high-multiplex plasma proteomics
- Pre-specified
- Serial sampling
- High-multiplex plasma proteomics
No results yet. This paper sets out the design of a trial; its results are to come.
Further findings
Planned analytic framework
- Five complementary approaches: limit-of-detection-based data filtering, limma-trend regression against TPA-LT/FIBA10, empirical Bayes moderated statistics across severity grades, linear mixed-effects modelling of longitudinal intra-patient trajectories, pathway-level enrichment analysis
- Semi-supervised pathway clustering analysis in eight a priori defined domains
- Olink Explore HT platform (≈5400 proteins)
- No results reported; analysis plan only
Original publication
Investigating Fibrinolysis Resistance in Sepsis Using High‐Multiplex Plasma Proteomics: A Statistical Analysis Plan. Acta Anaesthesiol Scand. Published 15 October 2026. doi:10.
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