Plasma mitochondrial-associated proteins scale with illness severity and predict outcome in suspected sepsis
Authors' conclusion
Higher plasma mitochondrial-associated protein abundance was associated with greater illness severity and worse short-term outcomes in suspected sepsis.
Study context
- Population
- Adults presenting to the ED with suspected sepsis, infection confirmed by independent adjudication
- Participants
- 213 adults
- Comparison
- Continuous plasma mitochondrial-associated protein score (per SD) vs illness severity and 72-h outcomes
- Primary endpoint
- Association of mitochondrial-associated protein score with illness severity and short-term outcomes
- Follow-up
- 72 hours
Methodological detailsprospective cohort, exploratory clustering
- Prospective cohort
- Exploratory clustering
Primary result
As reported in the abstract
Mitochondrial-associated protein score vs illness severity and 72-h outcomes · 72-hour
Correlation with illness severity (Spearman ρ; p < 0.01)
0.18-0.29
OR per SD, organ failure-free survival
0.57
OR per SD, ICU admission
1.66
OR per SD, mortality
2.36
Further findings
Exploratory clustering (PCA with K-means)
- Two groups differing mainly in overall mitochondrial-associated protein abundance; considerable overlap, variation along a continuum rather than distinct subphenotypes
- Exploratory
Exploratory pathway analyses
- Implicated mitochondrial metabolism, cellular stress and injury-related processes
- Exploratory
Original publication
Plasma mitochondrial-associated proteins scale with illness severity and predict outcome in suspected sepsis. Crit Care. Published 29 August 2026. doi:10.
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