Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure
Authors' conclusion
Sepsis and organ failure were closely associated with plasma H3.1 nucleosome concentrations.
Study context
- Population
- Consecutive critically ill ICU patients (MARS cohort)3,671 plasma samples
- Participants
- 1,713 patients
- Exposure
- H3.1 nucleosome concentrations by sepsis status and organ failure
- Outcome
- Baseline plasma H3.1 nucleosome concentration
- Follow-up
- Baseline
Methodological detailsconsecutive ICU patients, serial sampling days 0, 2 and 4
- Consecutive ICU patients
- Serial sampling days 0, 2 and 4
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR |
|---|---|
| Need for RRTCorrecting for mortality | 2.00 |
Association with SOFA score
- Correlation of H3.1 with SOFA score (r)
- 0.40
Organ failure and inflammatory subphenotype
- H3.1 higher in disseminated intravascular coagulation, AKI and hyperinflammatory sepsis
Original publication
Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure. Crit Care. Published 19 May 2025. doi:10.
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