H3.1 Nucleosomes to Predict Renal Replacement Therapy and Mortality in Sepsis—A Secondary Analysis of the SISPCT Randomized Control Trial
Primary result · 28-day mortality per one unit increase in log10 H3.1Result — go to the resultAdjusted hazard ratio 1.48 95% CI 1.07–2.04Authors' conclusion
Elevated levels of H3.1 nucleosomes at admission are associated with mortality and AKI requiring RRT.
Study context
- Population
- Patients with sepsis or septic shock from 33 ICUs in Germany, 2009–2013927 with complete renal replacement therapy (RRT) data
- Participants
- 971 patients
- Comparison
- Admission plasma H3.1 nucleosome levels as predictor of RRT and 28-day mortality
- Sepsisn = 443reference
- Septic shockn = 520
- Primary endpoint
- 28-day mortality and time to commencement of RRT
- Follow-up
- 28 days
Methodological detailsprospectively collected samples, multicentre, multivariable Cox regression
- Prospectively collected samples
- Multicentre
- Multivariable Cox regression
Primary result
As reported in the abstract
28-day mortality per one unit increase in log10 H3.1
Adjusted hazard ratio
1.48
95% CI 1.07–2.04
P = 0.02
log10 H3.1 (per unit increase)
aHR 1.48 (95% CI 1.07–2.04); P = 0.02
Per unit increase, as printed
Further findings
28-day RRT (acute kidney injury (AKI) requiring RRT)
| Adjusted HR (95% CI) | P value | ||
|---|---|---|---|
| One log10 increase of H3.1Risk of 28-day RRT increased by 80% | 1.8 (1.34–2.40) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
Admission plasma H3.1 levels, septic shock vs sepsis
P < 0.001
Plasma H3.1 in stage 3 AKI requiring RRT (subgroup), septic shock vs sepsis
P = 0.01
- 28-day RRT (AKI requiring RRT): multivariable Cox regression controlling for maximum lactate, procalcitonin, and C-reactive protein levels
Original publication
H3.1 Nucleosomes to Predict Renal Replacement Therapy and Mortality in Sepsis—A Secondary Analysis of the SISPCT Randomized Control Trial. Crit Care Med. Published 3 August 2026. doi:10.
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