Is It Time to Reassess Local Anesthetic and Adjuvant Mixtures? A Narrative Review of Practice, Evidence, and Risks
Study context
- Population
- Use of mixtures of local anesthetics or local anesthetic-adjuvant mixtures in regional anesthesia
- Comparison
- LA mixtures or LA-adjuvant mixtures in RA
- Outcome
- Chemical, pharmacologic and clinical implications of LA mixture use
Main finding
As reported in the abstract
- Critical limitations: risk of particle formation, lack of pharmacologic rationale, unclear propensity for systemic toxicity
- Unclear safety profile and equivocal clinical benefit of certain LA and LA-adjuvant mixtures
- Recent in vitro evidence: extensive crystallization in LA or LA-adjuvant mixtures, incl. lidocaine plus sodium bicarbonate
Original publication
Is It Time to Reassess Local Anesthetic and Adjuvant Mixtures? A Narrative Review of Practice, Evidence, and Risks. Anesthesiology. Published 24 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →