Respiratory failure & ventilation
Is quantitative pupillometry affected by ambient light? A prospective crossover study
Authors' conclusion
We corroborate previous findings that the level of ambient light affects QP parameters in critically ill patients.
Study context
- Population
- Adult patients requiring invasive ventilation, critical care setting
- Participants
- 20 patients
- Exposure
- Pupillometry under bright vs dark ambient light conditions
- Outcome
- Neurological Pupil index (NPi) compared across conditions (DC1 vs BC, BC vs DC2, DC1 vs DC2)
Main finding
As reported in the abstract
NPi
- Median Neurological Pupil index (NPi) significantly lower in BC vs DC1 in both eyes
- NPi decreased by 0.6 or more (in 25% of participants)
- Significant increase in median NPi of both eyes from BC to DC2
- No significant difference between DC1 and DC2
Observational data: associations, not effects.
Further findings
Other quantitative pupillometry (QP) parameters
- Differences in NPi driven by differences in most, but not all, QP parameters included in NPi
Original publication
Is quantitative pupillometry affected by ambient light? A prospective crossover study. J Clin Monit Comput. Published 10 April 2025. doi:10.
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