IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial*
Authors' conclusion
The use of vitamin C in adult patients with proven or suspected infection and vasopressor support is associated with high probability of harm.
Study context
- Population
- Adults in 35 ICUs with proven or suspected infection, vasopressor support, and no more than 24 hours of ICU admissionITT population
- Participants
- 435 vs 437
- Comparison
- IV vitamin C vs placebo
- Vitamin Cn = 435
- Placebon = 437reference
- Primary endpoint
- Composite of:
- Death
- Persistent organ dysfunction (vasopressor use, invasive mechanical ventilation, or new RRT)
- Follow-up
- 28 days
Methodological detailspost hoc Bayesian reanalysis, placebo-controlled, multicentre, Bayesian log-binomial models with random effects for hospital site and varying informative priors
- Post hoc Bayesian reanalysis
- Placebo-controlled
- Multicentre
- Bayesian log-binomial models with random effects for hospital site and varying informative priors
Primary result
As reported in the abstract
Vitamin C vs PlaceboRelative risk (95% CrI)
Weakly neutral priors; probability of harm, 99%
1.20(1.04–1.39)
Optimistic priors; probability of harm, 98%
1.14(1.00–1.31)
Empiric priors; probability of harm, 92%
1.09(0.97–1.22)
Further findings
| Outcome | RR (95% CrI) | |
|---|---|---|
| Death · 28 daysVitamin C vs Placebo · weakly neutral priors; probability of harm, 96% · CrI | 1.17 (0.98–1.40) | |
| Death · 28 daysVitamin C vs Placebo · optimistic priors; probability of harm, 88% · CrI | 1.10 (0.94–1.30) | |
| Death · 28 daysVitamin C vs Placebo · empiric priors; probability of harm, 76% · CrI | 1.05 (0.92–1.19) | |
| 0.512Relative risk (log scale) |
Original publication
IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial*. Crit Care Med. Published 7 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →