Perioperative medicine & outcomes
Laboratory Result Reference Ranges Stratified for Patient-Reported Sex and Ethnicity Are More Closely Associated With Postoperative Outcomes Than Currently Used Reference Ranges: A Retrospective Data Analysis
Authors' conclusion
Baseline "normal" laboratory values differ across sex and ethnic groups, and ranges stratified by these groups are better associated with postoperative AKI and mortality as compared to the standard reference ranges.
Study context
- Population
- Patients undergoing procedures; ranges derived from outpatient metabolic panels, complete blood counts and coagulation panels300 race × sex × laboratory combinations
- Exposure
- Sex/ethnicity-stratified vs nonstratified laboratory reference ranges
- Outcome
- Association of normal/abnormal classification with postoperative mortality and AKI (OR per outcome/laboratory result pair; frequency of non-overlapping CIs)
Methodological detailselectronic health record data
- Electronic health record data
Main finding
As reported in the abstract
Association with postoperative AKI and mortality where ORs differed
- Stratified range better associated with both acute kidney injury (AKI) and mortality (P < .001)
- No trend of bias toward any specific sex/ethnic group
Observational data: associations, not effects.
Further findings
Agreement of normal/abnormal classification between methods
- Median proportion overlap
- 0.86 [q1, 0.80; q3, 0.89]
- All laboratory results except 6 overlapped at least 80% of the time
- Frequency of overlap did not differ among racial/ethnic groups
Original publication
Laboratory Result Reference Ranges Stratified for Patient-Reported Sex and Ethnicity Are More Closely Associated With Postoperative Outcomes Than Currently Used Reference Ranges: A Retrospective Data Analysis. Anesth Analg. Published 24 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →