Hemodynamics, fluids & transfusion
Impacts of extreme temperature events on intraoperative hypotension: Evidence from a multicenter cohort study of 276,515 patients
Authors' conclusion
ETEs were associated with IOH, with heat waves reducing risk and cold spells increasing risk.
Study context
- Population
- Patients undergoing major surgery between 2015 and 2023 at three large academic centers
- Participants
- 276,515 patients · 3 academic centers
- Exposure
- Heat waves or cold spells vs no extreme temperature event exposure
- Heat wavesn = 48,023
- Cold spellsn = 42,615
- Unexposedn = 185,877reference
- Outcome
- IOH ≥10 min (MAP < 65 mmHg for ≥10 min)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
IOH ≥10 min
Each group vs unexposedAdjusted odds ratio (95 % CI)P value
Heat waves
0.80(0.76–0.84)
P < 0.001Cold spellsstrongest association: cold spells defined by the 2.5th percentile lasting 4 days
1.31(1.24–1.39)
P < 0.001Observational data: associations, not effects.
Secondary outcomes
Duration of intraoperative hypotension (IOH) ≥10 min
- Total difference in IOH duration across 30-day average temperatures from 0 to 30 °C
- ≈4 min
- Non-linear association of IOH duration with mean temperature 30 days prior to admission (restricted cubic spline)
- p-nonlinearity = 0.036
- Magnitude of cold-spell risk increased with longer IOH duration
Original publication
Impacts of extreme temperature events on intraoperative hypotension: Evidence from a multicenter cohort study of 276,515 patients. J Clin Anesth. Published 23 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →