Perioperative medicine & outcomes
Association between postoperative hypotension and acute kidney injury after noncardiac surgery: a historical cohort analysis
Authors' conclusion
Postoperative hypotension, defined as the lowest postoperative mean arterial pressure < 80 mm Hg, was associated with acute kidney injury after noncardiac surgery.
Study context
- Population
- Adults having noncardiac surgery with creatinine recorded preoperatively and postoperativelyanalysed
- Participants
- 64,349 adults
- Exposure
- Lowest postoperative MAP, below vs at or above 80 mm Hg
- Outcome
- AKI (KDIGO criteria); primary hypothesis: an absolute hypotensive arterial pressure threshold for AKI
- Follow-up
- Initial seven days after noncardiac surgery
Methodological detailssingle-centre, historical cohort, adjusted for confounders including intraoperative hypotension
- Single-centre
- Historical cohort
- Adjusted for confounders including intraoperative hypotension
Main finding
As reported in the abstract
AKI per 5-mm Hg decrease in lowest MAP
Odds ratio per 5-mm Hg decrease (97.5% CI)P value
Higher lowest pressuresnot associated with AKI
1.08(0.99–1.17)
P = 0.04Per 5-mm Hg decrease in lowest MAP, as printed
- Lowest MAP < 80 mm Hg
- increase in odds of AKI per 5-mm Hg decrease 28% (97.5% CI 23–32); P < 0.001
Observational data: associations, not effects.
Further findings
Postoperative AKI incidence (whole cohort)
- Patients with postoperative AKI
- 2,812 (4.4%)
Original publication
Association between postoperative hypotension and acute kidney injury after noncardiac surgery: a historical cohort analysis. Can J Anaesth. Published 2 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →