Levels of preoperative cerebrospinal fluid pro‐inflammatory mediators and chronic pain after total knee arthroplasty surgery
Authors' conclusion
We identified the CSF fractalkine level as a potential predictor for CPSP severity following TKA surgery.
Study context
- Population
- Patients undergoing elective total knee arthroplasty (TKA) for chronic knee arthralgiaanalysed
- Participants
- 42 patients
- Outcome
- CPSP severity (brief pain inventory (BPI))
- Follow-up
- 6 months postsurgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Preoperative cerebrospinal fluid (CSF) fractalkine vs chronic postsurgical pain (CPSP) severity, Spearman's rho
−0.525
p = .002
Preoperative PCS score, independent predictor of CPSP severity (multivariate linear regression), standardized β (95% CI 0.06-0.16; p < .001)
.11
CSF fractalkine level, independent predictor of CPSP severity (multivariate linear regression), standardized β (95% CI −1.10 to −0.15; p = .012)
−.62
Observational data: associations, not effects.
Further findings
Preoperative CSF mediator levels vs preoperative pain profiles
- No significant correlation
Original publication
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