Locoregional anesthesia in patients with Brugada syndrome. A retrospective database analysis
Authors' conclusion
In this retrospective study, our findings do not indicate an increased arrhythmogenic risk or a higher incidence of adverse events associated with the administration of local anesthetics in patients with BrS.
Study context
- Population
- Patients with Brugada syndrome (BrS) undergoing locoregional anesthesia, January 1, 1996 to September 30, 202047 procedures analysed
- Participants
- 27 / 13 / 9
- Exposure
- Peripheral nerve block (PNB) vs Epidural anesthesia vs Spinal anesthesia
- PNBn = 27
- Epidural anesthesian = 13
- Spinal anesthesian = 9
- Outcome
- Incidence of new malignant arrhythmias or defibrillation events after local anesthetic administration, perioperatively and postoperatively
- Follow-up
- Up to 30 days
Methodological detailsdatabase analysis
- Database analysis
Main finding
As reported in the abstract
New malignant arrhythmias or defibrillation events
PNB
1
events
- One PNB patient had intraoperative ventricular fibrillation following ajmaline administration
- 1
Observational data: associations, not effects.
Safety
- No other adverse events observed
Original publication
Locoregional anesthesia in patients with Brugada syndrome. A retrospective database analysis. Acta Anaesthesiol Scand. Published 12 January 2025. doi:10.
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