ICU sedation, delirium & recovery
Long term cognitive dysfunction among critical care survivors: associated factors and quality of life—a multicenter cohort study
Authors' conclusion
Delirium was found to be the main modifiable predictor of long-term cognitive dysfunction in ICU survivors. Higher education consistently reduced the probability of having long-term cognitive dysfunction. Cognitive dysfunction significantly influenced patients' quality of life
Study context
- Population
- Adult ICU survivors with ICU stay >72 h, ICUs of 10 tertiary hospitals in Brazil, May 2014–December 2018median age 60
- Participants
- 452 survivors
- Outcome
- Cognitive dysfunction (telephone Montreal Cognitive Assessment [tMOCA] score <12)
- Follow-up
- 12 months after ICU discharge
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Cognitive dysfunction (prevalence) · 12 months
ICU survivors
47.8%
216 events
Observational data: associations, not effects.
Further findings
Factors associated with 1-year cognitive dysfunction (multivariable analysis)
| PR | P value | |
|---|---|---|
| Older age | 1.44 | P < 0.001 |
| Absence of higher education | 2.81 | P = 0.005 |
| Higher comorbidities on admission | 1.089 | P = 0.004 |
| Delirium | 1.13 | P < 0.001 |
Health-related Quality of life (HRQoL) (SF-12v2 mental and physical dimensions), with vs without cognitive dysfunction
| Mean difference (95% CI) | P value | |
|---|---|---|
| Mental SF-12v2 | 2.54 (- 4.80/- 0.28) | P = 0.028 |
| Physical SF-12v2 | - 2.85 (- 5.20/- 0.50) | P = 0.018 |
- HRQoL significantly better in patients without cognitive dysfunction
Original publication
Long term cognitive dysfunction among critical care survivors: associated factors and quality of life—a multicenter cohort study. Ann Intensive Care. Published 29 July 2024. doi:10.
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