Long-term Health Outcomes of New Persistent Opioid Use After Surgery Among Medicare Beneficiaries
Main findingResult — go to the resultHazard ratio 3.44 CI 2.99–3.96Authors' conclusion
New persistent opioid use after surgery is associated with increased mortality and poorer health outcomes after surgery.
Study context
- Population
- Medicare beneficiaries ≥65 years undergoing surgery between January 1, 2009, and June 30, 2019
- Participants
- 229,898 beneficiaries
- Exposure
- New persistent opioid use vs no new persistent opioid use after surgery
- New persistent opioid usen = 6,874
- Outcome
- Mortality
- Follow-up
- 6 to 12 months after surgery
Methodological detailsclaims analysis, 20% national Medicare sample, multivariable adjusted
- Claims analysis
- 20% national Medicare sample
- Multivariable adjusted
Main finding
As reported in the abstract
Hazard ratio
3.44
CI 2.99–3.96
New persistent opioid use vs No new persistent opioid use
HR 3.44 (CI 2.99–3.96)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| Serious fall/fall-related injury · 6 to 12 months after surgery | 1.21 (1.05–1.39) | |
| Respiratory-related readmissions/ED visits · 6 to 12 months after surgery | 1.67 (1.49–1.86) | |
| Pain-related/opioid-related readmissions/ED visits · 6 to 12 months after surgery | 1.68 (1.55–1.82) | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Long-term Health Outcomes of New Persistent Opioid Use After Surgery Among Medicare Beneficiaries. Ann Surg. Published 14 November 2022. doi:10.
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