Long-term mortality after stage 1 acute kidney injury in critically ill patients - an observational cohort study
Main finding · One-year mortalityResult — go to the resultOdds ratio 1.6 95 % CI 1.48–1.73Authors' conclusion
Stage 1 AKI is associated with 1-year mortality in adult ICU patients even in steps below 26.5 μmol/L.
Study context
- Population
- Adult intensive care units (ICU) patients, two tertiary care centres in Switzerland and Austria (2013–2021)
- Participants
- 42,446 patients
- Exposure
- Stage 1 Acute Kidney Injury (AKI) vs no AKI
- Stage 1 AKIn = 4,667
- Moderate/severe AKIn = 5,449
- No AKIn = 32,330reference
- Outcome
- One-year mortality
- Follow-up
- One year
Methodological detailstwo tertiary care centres, multivariable regression, sensitivity analyses, Baseline creatinine determined using estimation formulas
- Two tertiary care centres
- Multivariable regression
- Sensitivity analyses
- Baseline creatinine determined using estimation formulas
Main finding
As reported in the abstract
Odds ratio
1.6
95 % CI 1.48–1.73
P < 0.001
Stage 1 AKI vs No AKI
OR 1.6 (95 % CI 1.48–1.73); P < 0.001
Observational data: associations, not effects.
Further findings
1-year mortality, patients with surgery (subgroup)
| OR (95% CI) | P value | ||
|---|---|---|---|
| With surgerySimilar association · subgroup analysis | 1.66 (1.45–1.89) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
1-year mortality, patients without surgery (subgroup)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Without surgerySimilar association · subgroup analysis | 1.61 (1.46–1.78) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
| Outcome | β (95% CI) | P value |
|---|---|---|
| ICU LOSStage 1 AKI vs No AKI · multivariable regression | 1.4 (1.2–1.5) | P < 0.001 |
| Hospital LOSStage 1 AKI vs No AKI · multivariable regression | 2.7 (2.1–3.2) | P < 0.001 |
Original publication
Long-term mortality after stage 1 acute kidney injury in critically ill patients - an observational cohort study. J Crit Care. Published 29 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →