Health outcomes according to severity of acute kidney injury at ICU admission: a population-based cohort study
Authors' conclusion
The presence and severity of AKI at the time of ICU admission are strongly associated with adverse health outcomes. Stage 2 and 3 AKI portend a similarly high risk of mortality.
Study context
- Population
- Adults (≥ 18 years) in Ontario, Canada with outpatient baseline creatinine admitted to ICU, 2009–2021105,671 (22%) with acute kidney injury (AKI)
- Participants
- 484,956 adults
- Exposure
- Kidney Disease Improving Global Outcomes (KDIGO) AKI stage 1, 2 or 3 vs no AKI at ICU admission
- Outcome
- Mortality
- Follow-up
- 90 days
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Main finding
As reported in the abstract
90-day mortality
Each group vs no AKIAdjusted odds ratio (95% CI)
Stage 1
1.89(1.85–1.93)
Stage 2
2.64(2.54–2.73)
Stage 3
2.54(2.45–2.63)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| KRT dependence · 90 daysStage 1 vs No AKI | 2.05 (1.79–2.34) | |
| KRT dependence · 90 daysStage 2 vs No AKI | 4.28 (3.40–5.40) | |
| KRT dependence · 90 daysStage 3 vs No AKI | 8.61 (7.71–9.62) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Original publication
Health outcomes according to severity of acute kidney injury at ICU admission: a population-based cohort study. Intensive Care Med. Published 5 February 2026. doi:10.
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