Epidemiology and long-term outcomes of critically ill patients with severe acute kidney injury (AKI) in India and Southeast Asia
Authors' conclusion
Patients with severe AKI face a high incidence of 2-year MAKE and poor long-term clinical outcomes.
Study context
- Population
- Critically ill patients with AKI stage 3 (Kidney Disease Improving Global Outcomes (KDIGO) criteria), 24 hospitals in Southeast Asia and India, April 2019–December 20231,033 (47%) died in hospital
- Participants
- 2,315 patients
- Outcome
- MAKE: composite of persistent kidney dysfunction, long-term dialysis and all-cause mortality
- Follow-up
- 2 years post-enrollment
Main finding
As reported in the abstract
Incidence of 2-year MAKE among surviving patients · 2 years
Incidence of 2-year major adverse kidney events (MAKE)
46.6
per 100 person-years; 95% CI 42.7–50.6
Mortality as dominant component of MAKE
32%
Observational data: associations, not effects.
Further findings
New chronic kidney disease (CKD) · 2 years post-AKI
- Incidence per 100 person-years
- 58.6 (95% CI 51.0-67.0)
CKD progression · 2 years post-AKI
- Incidence per 100 person-years
- 35.4 (95% CI 26.0-47.0)
Independent risk factors for 2-year MAKE (multivariable-adjusted)
- Older age, male sex, preexisting CKD, malignancy, cardiac-associated AKI and non-recovery of kidney function after AKI
Original publication
Epidemiology and long-term outcomes of critically ill patients with severe AKI in India and Southeast Asia. Intensive Care Med. Published 14 July 2025. doi:10.
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