Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis
Authors' conclusion
Biomarker-defined sAKI is a common and severe condition observed in patients within intensive care units with a urinary peptide signature that is similar to that of AKI, along with a comparable prognosis.
Study context
- Population
- ICU patients with all biomarkers measured at inclusion1,154 without acute kidney injury (AKI)
- Participants
- 1,885 patients
- Comparison
- Urinary peptide signatures of biomarker-defined subclinical AKI vs AKI
- non-AKIKDIGOn = 1,154
- Primary endpoint
- Urinary peptide signature of sAKI (capillary electrophoresis-mass spectrometry)
- Follow-up
- At study inclusion
Methodological detailsancillary analysis, prospective, observational, multinational
- Ancillary analysis
- Prospective
- Observational
- Multinational
Primary result
As reported in the abstract
Urinary peptide signature
- sAKI signatures, regardless of biomarker used, similar to AKIKDIGO signatures (inflammation, haemolysis, endothelial dysfunction)
Further findings
- Mortality, non-AKIKDIGO subgroup (median age 60 years [48, 71]) — non-AKIKDIGO
- 27.8%
1-year mortality
- Signatures associated with 1-year mortality
Original publication
Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis. Intensive Care Med. Published 5 September 2023. doi:10.
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