Neuroanesthesia & neurocritical care
Long-term outcome in new onset refractory status epilepticus: a retrospective study
Authors' conclusion
Our data suggest that the long-term outcome can still be favorable in NORSE survivors, despite a prolonged and complicated ICU stay.
Study context
- Population
- Adults with new onset refractory status epilepticus (NORSE) admitted to the Neurocritical Care Unit, University Hospital Zurich, Switzerland, 01.2010–12.2022of 283 adults with SE
- Participants
- 25 adults
- Outcome
- In-hospital and long-term mortality; functional outcome (mRS) in hospital survivors
Methodological detailssingle-centre, descriptive statistics
- Single-centre
- Descriptive statistics
Main finding
As reported in the abstract
In-hospital mortality
36%
n = 9
Mortality at last available follow-up (on average 30 months after ICU admission)
56%
n = 14
Functional outcome improved over time in hospital survivors
13 of 16
81%
Median mRS at hospital discharge vs at last available follow-up
4 [3.75-5] vs. 2 [1.75-3]
p < 0.001
Observational data: associations, not effects.
Further findings
Patient characteristics
- Female
- 68%
- Charlson comorbidity index
- 1 [0-4]
- Age (years)
- 54 ± 17
- Super-refractory SE
- 96%
- Cryptogenic
- 68%
End-of-life decisions
- End of life (EOL) decision taken, days after ICU admission
- 29 [12-51]
- Death after the decision, day
- 6 [1-8.5]
- Decision triggered by medical staff except for one patient
Original publication
Long-term outcome in new onset refractory status epilepticus: a retrospective study. Crit Care. Published 12 March 2024. doi:10.
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