Perioperative medicine & outcomes

Long-term Outcomes with Spinal versus General Anesthesia for Hip Fracture Surgery: A Randomized Trial

AnesthesiologyPublished Prespecified analysis of long-term outcomes of a randomised controlled trial

Primary result · DeathsResult — go to the resultHazard ratio 1.08 95% CI 0.81–1.44

Authors' conclusion

Long-term outcomes were similar with spinal versus general anesthesia.

Study context

Population
Previously ambulatory patients ≥50 yr undergoing hip fracture repair at 46 US and Canadian hospitalsvital status available for 1,427 (89.2%)
Participants
1,600 patients
Comparison
Spinal vs general anaesthesia for hip fracture repair
  • Spinaln = 795
  • Generaln = 805reference
Primary endpoint
Survival
Follow-up
Up to 365 days after randomization
Methodological detailssuperiority, multicentre, stratified randomisation, masked outcome assessment
  • Superiority
  • Multicentre
  • Stratified randomisation
  • Masked outcome assessment

Primary result

Deaths

Hazard ratio

1.08

95% CI 0.81–1.44

P = 0.59

Events by treatment group

Spinal

98

events

General

92

events

Spinal vs General
HR 1.08 (95% CI 0.81–1.44); P = 0.59

As reported in the abstract

Further findings

OutcomeaOR for recovery of ambulation (95% CI)P value
Recovery of ambulation among 1-yr survivors · up to 365 daysDid not differ by type of anesthesia0.87 (0.67–1.14)P = 0.31

Other outcomes (composites of death or new inability to ambulate and death or new nursing home residence at 365 days)

Did not differ by treatment arm

Original publication

Long-term Outcomes with Spinal versus General Anesthesia for Hip Fracture Surgery: A Randomized Trial. Anesthesiology. Published 13 October 2023. doi:10.1097/aln.0000000000004807

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