Perioperative medicine & outcomes
Long-term survival and functional outcomes of critically ill patients with hematologic malignancies: a Canadian multicenter prospective study
Authors' conclusion
49% of all HM patients were alive at 7 days post-ICU discharge, and 21% at 12 months.
Study context
- Population
- Patients with hematologic malignancy admitted to 7 Canadian intensive care units (ICUs) (2018–2020)
- Participants
- 414 patients
- Outcome
- Survival
- Follow-up
- 12 months
Methodological detailsmulticentre, 7 Canadian ICUs
- Multicentre
- 7 Canadian ICUs
Main finding
As reported in the abstract
12-month survival
12-month survival, entire cohort
21%
12-month survival, ICU survivors
43%
Observational data: associations, not effects.
Further findings
Alive 7 days post-ICU discharge (ICU survivors)
- Alive 7 days post-ICU discharge
- 203 (49%)
Moderate-severe frailty among survivors (CFS ≥ 6)
- At 7 days
- 42%
- At 6 months
- 14%
- At 12 months
- 8%
Functional independence measure (functional independent measure (FIM)) · 7 days
- Median FIM (IQR: 50-109)
- 80
SF-36 domains · 6 and 12 months
- Physical function, pain, social function, mental health and emotional well-being below age- and sex-matched population scores
Variables associated with 12-month survival
- Frailty, allogeneic HCT, kidney injury and cardiac complications during ICU associated with lower 12-month survival
Original publication
Long-term survival and functional outcomes of critically ill patients with hematologic malignancies: a Canadian multicenter prospective study. Intensive Care Med. Published 11 March 2024. doi:10.
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