Perioperative medicine & outcomes
Risk factors for postoperative cognitive dysfunction in elderly patients undergoing surgery for oral malignancies
Authors' conclusion
Venerable age, low knowledge reserve, hypertension, dyssomnia, prolonged anaesthesia, and intraoperative hypotension are independent risk factors for POCD in elderly patients with oral malignancies.
Study context
- Population
- Elderly patients (aged ≥ 55 years) undergoing expanded resection of oral malignancy and cervical lymphatic dissection, December 2020 to December 2021
- Participants
- 112 patients
- Exposure
- Postoperative cognitive dysfunction (POCD) vs non-POCD at 7 days after surgery
- POCDn = 37
- Outcome
- POCD incidence (neuropsychological test scale) and risk factors
- Follow-up
- 7 days after surgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
POCD incidence and independent risk factors (multiple factor logistic regression)
POCD
33.1%
37
Odds ratio (95% CI)P value
Venerable age
1.269(1.056–1.525)
P < 0.05Low education levels
0.792(0.644–0.974)
P < 0.05Hypertension
4.153(1.335–12.732)
P < 0.05Dyssomnia
1.272(1.001–1.617)
P < 0.05Prolonged anaesthesia
1.009(1.001–1.018)
P < 0.05Intraoperative hypotension
5.512(1.240–24.506)
P < 0.05Observational data: associations, not effects.
Original publication
Risk factors for postoperative cognitive dysfunction in elderly patients undergoing surgery for oral malignancies. Perioper Med (Lond). Published 20 July 2023. doi:10.
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