Neuroanaesthesia & neurocritical care
Low baseline transcranial motor evoked potential (Tc-MEP) amplitude is associated with false-positive alerts in spine surgery: a ROC-based analysis across spinal pathologies
Authors' conclusion
Lower baseline Tc-MEP amplitudes were associated with FP alerts.
Study context
- Population
- High-risk spine surgery cases monitored with Tc-MEPs, 2018 to 20201,748 waveforms analysed
- Participants
- 307 cases
- Exposure
- Baseline Tc-MEP amplitude in false-positive (FP) vs true-negative waveforms
- FPn = 253
- Outcome
- Association of absolute baseline Tc-MEP amplitude with FP alerts; pathology-specific cutoff values
Methodological detailsROC analysis, waveform-level analysis
- ROC analysis
- Waveform-level analysis
Main finding
As reported in the abstract
Baseline Tc-MEP amplitude
Observational data: associations, not effects.
Further findings
- FP alert incidence (waveforms)
- 14.5% · 253
FP alert incidence (waveforms)
- FP alerts more frequent in lower-extremity recordings
Exploratory ROC-derived baseline-amplitude cutoffs for FP alerts, by pathology
- Spinal cord tumor surgery: cutoff (µV)
- 122
- Spinal cord tumor surgery: AUC
- 0.68
- Spinal deformity surgery: cutoff (µV)
- 180
- Spinal deformity surgery: AUC
- 0.56
- OPLL surgery: cutoff (µV)
- 160
- OPLL surgery: AUC
- 0.61
- Pooled cohort: cutoff (µV)
- 170
- Pooled cohort: AUC
- 0.61
- Exploratory
Original publication
Low baseline Tc-MEP amplitude is associated with false-positive alerts in spine surgery: a ROC-based analysis across spinal pathologies. J Clin Monit Comput. Published 28 September 2026. doi:10.
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