Low expression of CD39 on monocytes predicts poor survival in sepsis patients
Authors' conclusion
Low CD39 expression on monocytes might serve as a potential diagnostic biomarker and a strong predictor of poor prognosis in sepsis patients.
Study context
- Population
- Healthy donors, patients with mild infections, post-cardiac surgery patients and sepsis patients, First Affiliated Hospital, Zhejiang University School of Medicine, April 2022–September 2023
- Participants
- 206 donors
- Exposure
- Monocytic CD39 expression in sepsis vs mild infection, post-cardiac surgery and healthy donors
- Outcome
- Monocytic CD39 (mCD39) expression and diagnostic performance
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
| Group | AUC (sepsis vs mild infection) | AUC (sepsis vs non-infectious inflammation) |
|---|---|---|
| Mild infection | 0.877 | — not stated in the abstract |
| Post-surgery | — not stated in the abstract | 0.935 |
AUC (sepsis vs mild infection)
Mild infection0.877
Post-surgery— not stated in the abstract
AUC (sepsis vs non-infectious inflammation)
Mild infection— not stated in the abstract
Post-surgery0.935
— not stated in the abstract
- Significantly lower monocytic CD39 (mCD39) expression in sepsis than in mild infection and post-surgery groups
- P < 0.05
Observational data: associations, not effects.
Further findings
7-day survival prediction by low mCD39 (sepsis)
- AUC
- 0.85
- P
- P = 0.037
28-day survival, low vs high mCD39 (sepsis, Kaplan-Meier)
- 28-day survival, low vs other mCD39
- 56.7% vs. 80.6%
- P
- P = 0.016
Original publication
Low expression of CD39 on monocytes predicts poor survival in sepsis patients. J Intensive Care. Published 10 March 2025. doi:10.
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