Perioperative medicine & outcomes
Low Preoperative Serum Creatinine is Common and Associated With Poor Outcomes After Nonemergent Inpatient Surgery
Authors' conclusion
A low preoperative creatinine is common and associated with poor outcomes after nonemergent inpatient surgery.
Study context
- Population
- Patients with creatinine in the 7 days preceding nonemergent inpatient surgery, ACS NSQIP database, 2005 to 2020
- Participants
- 1,809,576 patients
- Exposure
- Low preoperative serum creatinine vs reference creatinine range, by sex
- Outcome
- Mortality and major complications
- Follow-up
- 30-day
Methodological detailsregistry database (ACS NSQIP), multivariable logistic regression
- Registry database (ACS NSQIP)
- Multivariable logistic regression
Main finding
As reported in the abstract
30-day mortality and major complications
Estimate (95% CI)
Males ≤0.44 vs Males 0.85 to 1.04
aOR (mortality) 1.55(1.29–1.86)
Males ≤0.44 vs Males 0.85 to 1.04
aOR (major complications) 1.82(1.69–1.97)
Females ≤0.44 vs Females 0.65 to 0.84
aOR (mortality) 1.49(1.32–1.67)
Females ≤0.44 vs Females 0.65 to 0.84
aOR (major complications) 1.76(1.70–1.83)
Observational data: associations, not effects.
Further findings
Prevalence of low preoperative serum creatinine and overall outcomes
- Males with low preoperative serum creatinine
- 27.8%
- Females with low preoperative serum creatinine
- 23.5%
- Experienced complications
- 14.6%
- Died
- 1.2%
Total cohort, mildly low albumin, creatinine measured 8 to 30 days preoperatively (subgroup)
- Associations persisted
Original publication
Low Preoperative Serum Creatinine is Common and Associated With Poor Outcomes After Nonemergent Inpatient Surgery. Ann Surg. Published 28 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →