Hemodynamics, fluids & transfusion
Low-Range Heparin and Protamine Detection: A Single-Center Prospective Diagnostic Study
Authors' conclusion
We were able to confirm that the Sonoclot slope-45 has a high sensitivity for low-dose heparin, which is retained in the setting of interacting protamine. It was insensitive to protamine in itself.
Study context
- Population
- Blood samples from healthy volunteers treated ex vivo with incremental low doses of heparin, protamine, or their combination
- Participants
- 10 healthy volunteers
- Comparison
- aXa, aPTT, iSTAT kACT, ROTEM clotting time ratio and Sonoclot slope-45 for low-dose heparin and protamine
- Outcome
- Detection of low heparin activity in heparin-spiked blood
Methodological detailsprospective, in vitro, single-centre
- Prospective
- In vitro
- Single-centre
Performance
As reported in the abstract
- All parameters except iSTAT kACT reliably detected low heparin activity
Further findings
Effect of protamine, alone and combined with heparin
- No impact on aXa, aPTT, iSTAT kACT, ROTEM clotting time ratio or Sonoclot slope-45
Original publication
Low-Range Heparin and Protamine Detection: A Single-Center Prospective Diagnostic Study. J Cardiothorac Vasc Anesth. Published 17 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →