Cardiothoracic & vascular anesthesia
Concordance of Activated Partial Thromboplastin Time and Anti‒Factor Xa Levels in Monitoring Heparin Therapy Among Cardiac Surgery Patients in Pre- and Postoperative Settings
Authors' conclusion
Significant discordance exists in aPTT-anti-Xa assay results, particularly in the postoperative period. Diabetes was the only significant predictor of discordance, suggesting metabolic status may influence assay agreement.
Study context
- Population
- Adults (≥18 years) undergoing cardiac surgery with CPB on perioperative heparin infusion, quaternary care hospitalpaired samples, 112 patients
- Participants
- 589 adults
- Exposure
- Preoperative vs postoperative aPTT–anti-Xa concordance
- Preoperativen = 377reference
- Postoperativen = 212
- Outcome
- Discordant paired measurements
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Predictors of discordance, postoperative cohort (diabetes vs no diabetes) | 0.32 (0.11–0.89) | P = 0.031 | |
| 0.10.31310Odds ratio (log scale) |
- Predictors of discordance, postoperative cohort (diabetes vs no diabetes): unadjusted mixed-effects logistic regression; only significant predictor
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Concordance of Activated Partial Thromboplastin Time and Anti‒Factor Xa Levels in Monitoring Heparin Therapy Among Cardiac Surgery Patients in Pre- and Postoperative Settings. J Cardiothorac Vasc Anesth. Published 23 June 2026. doi:10.
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