Respiratory failure & ventilation
Low Tidal Volume Ventilation Is Poorly Implemented for Patients in North American and United Kingdom ICUs Using Electronic Health Records
Authors' conclusion
There has been limited implementation of LTVV in routine clinical practice in the United Kingdom and the United States. VT > 8 mL/kg PBW was associated with worse patient outcomes.
Study context
- Population
- Patients mechanically ventilated for > 48 h in UK and US ICUs
- Participants
- 5,466 vs 7,384
- Exposure
- Factors associated with adherence to low tidal volume ventilation
- CCHICn = 5,466
- eICU-CRDn = 7,384
- Outcome
- Factors associated with adherence to LTVV (median VT > 8 mL/kg PBW)
Methodological detailsmulticentre, electronic health record databases
- Multicentre
- Electronic health record databases
Main finding
As reported in the abstract
Median VT and risk of median VT > 8 mL/kg PBW
Odds ratio (95% CI)
BMI > 30 kg/m² (CCHIC)
1.9(1.7–2.13)
BMI > 30 kg/m² (eICU-CRD)
1.61(1.49–1.75)
Female (CCHIC)
2.39(2.16–2.65)
Female (eICU-CRD)
2.29(2.26–2.31)
Observational data: associations, not effects.
Further findings
30-day mortality, median VT < 8 mL/kg PBW
| Cause-specific HR (95% CI) | ||
|---|---|---|
| VT < 8 mL/kg PBW (CCHIC) | 0.86 (0.76–0.97) | |
| VT < 8 mL/kg PBW (eICU-CRD) | 0.9 (0.86–1.00) | |
| 0.512Cause-specific hazard ratio (log scale) |
VT over time
- Significant reduction in VT over time in CCHIC
Original publication
Low Tidal Volume Ventilation Is Poorly Implemented for Patients in North American and United Kingdom ICUs Using Electronic Health Records. Chest. Published 27 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →