Hemodynamics, fluids & transfusion
Low Versus High Blood Pressure Targets in Critically Ill and Surgical Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials*
Pooled resultResult — go to the resultRelative risk 0.93 95% CI 0.87–0.99Authors' conclusion
Based on pooled randomized trial evidence, a lower compared with a higher blood pressure target results in a reduction of mortality, atrial fibrillation, and transfusion requirements.
Study context
- Population
- Critically ill and perioperative patients
- Participants
- 15,672 participants · 28 RCTs
- Comparison
- Lower vs higher BP targets
- Lower blood pressure targetsn = 7,679
- Higher blood pressure targetsn = 7,649reference
- Outcome
- All-cause mortality
- Follow-up
- Longest available
Methodological detailsBayesian analysis
- Bayesian analysis
Pooled result
As reported in the abstract
Relative risk
0.93
95% CI 0.87–0.99
P = 0.03
Events by group
Low BP target vs High BP target
RR 0.93 (95% CI 0.87–0.99); P = 0.03
- Bayesian probability of any increase in mortality (as printed)
- 97.4%
Further pooled results
Sensitivity analyses (incl. low risk of bias studies)
- Findings mainly driven by ICU studies and treatment >24 hours; magnitude and direction similar in the majority of sensitivity analyses
AF and transfusion
- Lower rate of AF and fewer patients requiring transfusion with low-pressure targets
Other secondary outcomes
- No differences found
Original publication
Low Versus High Blood Pressure Targets in Critically Ill and Surgical Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials*. Crit Care Med. Published 24 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →