Low versus standard calorie and protein feeding and renal dysfunction in ventilated adults with shock: a NUTRIREA-3 post hoc analysis
Primary result · AKD during ICU stayResult — go to the resultHazard ratio 0.97 95% CI 0.88–1.07Authors' conclusion
In critically ill patients with shock, early low-calorie and low-protein nutrition for 7 days was not associated with worse renal outcomes or mortality compared to standard feeding, even in patients with preexisting renal dysfunction.
Study context
- Population
- Mechanically ventilated adults with shock
- Participants
- 3,036 participants
- Comparison
- Low vs standard calorie and protein feeding during the first 7 days
- Primary endpoint
- Incidence of acute kidney disease (AKD) during the ICU stay
- Follow-up
- Up to ICU discharge or day 90 after inclusion, whichever occurred first
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
AKD during ICU stay
Hazard ratio
0.97
95% CI 0.88–1.07
P = 0.53
Events by treatment group
Low vs Standard
HR 0.97 (95% CI 0.88–1.07); P = 0.53
As reported in the abstract
Further findings
| Outcome | P value |
|---|---|
| Highest urea level and urea level at ICU discharge | P = 0.002 |
Highest urea level and urea level at ICU discharge
- Significantly lower in the low group
RRT requirements and other renal outcomes
- No differences
Patients with early kidney dysfunction, severe organ failures, or end-stage CKD (subgroup)
- Results similar
Original publication
Low versus standard calorie and protein feeding and renal dysfunction in ventilated adults with shock: a NUTRIREA-3 post hoc analysis. Intensive Care Med. Published 16 April 2026. doi:10.
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