Respiratory failure & ventilation
Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis
Pooled result · All-cause mortalityResult — go to the resultRelative risk 0.99 95% CI 0.92–1.07Authors' conclusion
This study reported no overall differences comparing a PaO2 target of 8-12 kPa on mortality or days alive without life support in 90 days.
Study context
- Population
- Adult intensive care unit (ICU) patients with acute hypoxemic respiratory failure2 RCTs
- Participants
- 1,792 vs 1,793
- Comparison
- Pressure of arterial oxygen (PaO2) target 8 kPa vs 12 kPa
- 8 kPan = 1,792
- 12 kPan = 1,793reference
- Outcome
- All-cause mortality
- Follow-up
- 90 days
Methodological detailspre-specified, heterogeneity of treatment effects (HTE) evaluated in 14 subgroups, graded with ICEMAN
- Pre-specified
- HTE evaluated in 14 subgroups, graded with ICEMAN
Pooled result
As reported in the abstract
Relative risk
0.99
95% CI 0.92–1.07
P = 0.80
Events by group
8 kPa vs 12 kPa
RR 0.99 (95% CI 0.92–1.07); P = 0.80
Further pooled results
Days alive without life support · 90 days
- No difference observed
Days alive without life support (COVID-19 subgroup)
- More days alive without life support targeting 8 kPa
- P = 0.04
- Moderate credibility
Mortality (cancer subgroup)
- Lower mortality targeting 12 kPa
- P = 0.03
- Low credibility
Days alive without life support (cancer subgroup)
- More days alive without life support targeting 12 kPa
- P = 0.02
- Low credibility
Original publication
Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis. Intensive Care Med. Published 11 July 2024. doi:10.
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