Respiratory failure & ventilation
Oxygenation Targets and Long-Term Cognitive and Pulmonary Functions in Hypoxemic Respiratory Failure: A Clinical Trial
Authors' conclusion
A PaO2 target of 60 versus 90 mm Hg appeared to result in similar cognitive impairment but might reduce pulmonary diffusion capacity in ICU survivors of hypoxemic respiratory failure included in this 1-year follow-up.
Study context
- Population
- ICU survivors of acute hypoxemic respiratory failure at 1 yearof 1,244 eligible survivors
- Participants
- 417 survivors
- Comparison
- PaO2 target 60 vs 90 mm Hg
Methodological detailspreplanned 1-year follow-up
- Preplanned 1-year follow-up
Further findings
| Outcome | Lower oxygenation | Higher oxygenation | Adjusted mean difference (95% CI) | |
|---|---|---|---|---|
| Cognitive function (global RBANS score) · 1 yearMean | 78 (SD 19) | 76 (SD 21) | 2 (−2 to 6) | |
| n assessed | 187 | 188 | ||
| −50510Difference (linear scale) |
| Outcome | Lower oxygenation | Higher oxygenation | Adjusted mean difference (percentage points) (95% CI) | |
|---|---|---|---|---|
| Pulmonary function (% predicted DLCO) · 1 yearMean | 68% (SD 22) | 73% (SD 25) | −5 (−9 to −1) | |
| n assessed | 192 | 195 | ||
| −10−505Difference, percentage points (linear scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Oxygenation Targets and Long-Term Cognitive and Pulmonary Functions in Hypoxemic Respiratory Failure: A Clinical Trial. Am J Respir Crit Care Med. Published 8 September 2025. doi:10.
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