Respiratory failure & ventilation
Lower or Higher Oxygenation Targets in Patients With COVID-19 in the ICU: A Secondary Bayesian Analysis of the Handling Oxygenation Targets in COVID-19 Trial
Primary result · Days alive without life supportResult — go to the resultMean difference 5.7 days 95% CrI 0.2–11.2- Trial stopped after enrolling 726 of 780 planned patients because of slow recruitment
Authors' conclusion
In patients with COVID-19 and hypoxemia in the ICU, we found a high probability for a clinically relevant benefit of targeting a Pao2 of 60 mm Hg vs 90 mm Hg on number of days alive without life support.
Study context
- Population
- Adults with COVID-19 and hypoxemia in the ICUITT population
- Participants
- 697 adults
- Comparison
- PaO2 target 60 mm Hg vs 90 mm Hg
- Primary endpoint
- Days alive without life support (clinically relevant benefit > 1 day)
- Follow-up
- 90 days
Methodological detailspreplanned Bayesian analysis, Bayesian general linear models, heterogeneity of treatment effects analysis
- Preplanned Bayesian analysis
- Bayesian general linear models
- Heterogeneity of treatment effects analysis
Primary result
Days alive without life support
Mean difference
5.7 days
95% CrI 0.2–11.2
Lower target vs Higher target
mean difference 5.7 days (95% CrI 0.2–11.2)
As reported in the abstract
- Probability of clinically relevant benefit from lower target
- 95.2%
- Probability of any benefit from lower target
- 98.0%
Further findings
| Outcome | Risk difference (percentage points) (95% CrI) | |
|---|---|---|
| 90-day mortality · 90 daysLower target vs Higher target · 95% CrI · CrI | −4.6 (−11.8 to 2.6) | |
| −15−10−505Difference, percentage points (linear scale) |
- 90-day mortality — Probability of clinically relevant benefit (> 2 percentage points lower mortality) from lower target
- 76.5%
Heterogeneity of treatment effects (subgroup)
- Potential interaction with baseline norepinephrine dose and lactate concentrations for both outcomes
Original publication
Lower or Higher Oxygenation Targets in Patients With COVID-19 in the ICU: A Secondary Bayesian Analysis of the Handling Oxygenation Targets in COVID-19 Trial. Chest. Published 18 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →